melo-, mel-, -melia +
(Greek: melos, limb, body extremity or member; a condition of the limbs or extremities of a body; such as, arms, hands, fingers, legs, feet, toes, etc.)
Acromelalgia is a condition affecting the extremities, especially the feet, and marked by burning and throbbing sensations that come and go.
The throbbing and burning pain in the skin is often caused by exertion or heat, affecting the hands and feet, accompanied by a dusky mottled redness of the parts with increased skin temperature.
2. Congenital absence of a limb or limbs.
Usually the associated shoulder girdle or, less commonly, the associated pelvic girdle is also hypoplastic. A small soft-tissue protuberance may be present at the site of the missing limb.
Amelia is an extremely rare anomaly now. Between 1958 and 1963, it occurred with some frequency as a result of thalidomide embryopathy.
Analysis of the thalidomide anomalies showed that the drug produced limb defects only when taken between the 35th and 45th days after the last menstrual period.
Exposure during the early part of the vulnerable period led to very severe arm defects; such as, amelia or one-finger phocomelia; later exposure led to three-finger phocomelias and femoral and tibial defects.
Exposure near the end of the seventh week resulted only in minor thumb deformities (triphalangia). Exposure after fifty days of postmenstruation was associated with few or no fetal abnormalities.
2. A skeletal dysplasia characterized by a bending of the long bones of the limbs (arms and legs), resulting in a permanent bowing or curvature of the affected part or parts.
Long, slender fingers can be normal and not associated with any medical problems; however, in some cases, the tendency to develop spider fingers can indicate an underlying disease.
2. Congenital abnormality characterized by missing or foreshortened limbs, sometimes with associated spine abnormalities; caused by metabolic disturbance at the time of primordial limb development.
The normally associated pectoral or pelvic girdle is usually present but may be reduced. A fleshy tab is sometimes seen at the site of the missing limb. Also called amelia.
2. Characterized by a congenital absence of one or more limbs.
2. A rare disorder of middle age, characterized by paroxysmal attacks of severe burning pain, reddening, hyperalgesia and sweating, involving one or more extremities, usually both feet; the attacks can be triggered by heat, and are usually relieved by cold and limb elevation.
3. A disease affecting the feet and sometimes the hands, marked by paroxysmal, bilateral vasodilation with burning pain, increased skin temperature, and redness.