(Latin: an insoluble protein that is an essential part of blood coagulation)
2. An insoluble protein that is essential to the clotting of blood, formed from fibrinogen with the action of thrombin (key blood clot promoter).
The substance is produced in threads; after the threads have formed a close meshwork through the blood, they contract, and produce a dense, felted mass.
Fibrin is found in all inflammatory conditions within serous cavities like the pleura, peritoneum, and pericardium, and forms a thick coat upon the surface of the inflamed joints, and in the lung as a result of pneumonia.
2. A soluble protein present in the blood that is activated by thrombin to form fibrin.
Fibrinogen is a clotting factor and is required to prevent major blood loss.
2. The reduction or decrease in the amount of fibrinogen in the blood, usually because of a liver disorder.
2. A homogenous acellular material similar to fibrin, found normally in the placenta and formed in connective tissue and in the walls of blood vessels in certain disease conditions.
2. The dissolution of fibrin by enzymatic action.
3. A complicated system of biochemical reactions for lysis (dissolution or destruction of cells such as blood cells) of clots in the vascular system.
The insoluble protein fibrin is broken down by the enzyme plasmin which is activated at the same time as the coagulation process of blood.
There is normally a balance between coagulation and fibrinolysis; an abnormal increase in the latter causes excessive bleeding.