To separate into four directions, areas, or zones: It is possible that some very large rivers quadrifurcate when they separate and flow into four different channels.

Characteristic of being divided into four forks or branches: The surgeon found quadrifurcated veins in Patricia's leg which needed special medical attention so she could walk and run comfortably again.

The cartographers, or map makers, noticed that the large quadrifurcated river was flowing through the marshes on the edge of the lake.