1. In medicine, an operation in which an artificial opening is made into the labyrinth of the ear: This medical fenestration is a procedure that is performed to treat deafness associated with otosclerosis.
2. The establishment of a fistulous opening (fenestra): Dr Pink scrutinized the fenestration that he needed in order to bypass the bodily obstruction and then to continue with the operation.
3. In architecture, the arrangement and design of windows in a building: The architect created the house regarding the aspect of fenestration, making sure that the sun would light up the rooms beautifully.
4. The creation of an opening in a medical dressing or cast that allows a medical person to examine or to treat an injury: Dr. Smith made sure that the fenestration was placed correctly so that he could supervise the injury withougt complications.

A surgical procedure to create an epithelialised mucocutaneous opening from the neck into the trachea: Tracheal fenestration is mainly performed for airway access in order to remove secretions and to assist patients with chronic respiratory illnesses.