1. To give up possession or occupancy of: George's business must vacate the offices by next month.

Jerry and Doris will have to vacate their apartment when their lease expires.

2. To give up or to relinquish, to leave a position, an office, etc.: Because Jim was going to be on a sabbatical leave for a year, he vacated his position at the office.
3. To render inoperative; to deprive of validity; to make legally void: Jack was proven to be innocent of the criminal charges and so his pending sentence was vacated.