1. To separate from others or to set aside from a main body or association: It is considered wrong to segregate disabled people from the rest of society.

During apple harvests, damaged fruit is segregated from the main crop and used for making cider.

2. To impose the isolation of a race or class from the rest of society: Historically, lepers were commonly segregated from the rest of the population because they were thought to be highly infectious, so those who were not contaminated with leprosy segregated the lepers into places away from the other inhabitants.