An animal disease that requires both a vertebrate host and a nonanimal (food, soil, plant) source or developmental location for the culmination of its life cycle.

Examples include:

• Botulism, a paralytic, often fatal illness, caused by ingestion of food contaminated with a preformed toxin.
• Coccidioidomycosis, an infection which is limited to the lungs and caused by inhalation of spores.
• Ascariasis, infestation of the gastrointestinal tract that may produce diarrhea and anorexia.
• Tungiasis, a disease caused by the chigoe flea, the female of which penetrates the human skin, often under the toenail, where she becomes greatly distended with eggs, causing a painful ulcer and inflammation.