1. To adjust or to adapt to a certain proportion; to regulate: In order to have the radio turned down low is to modulate the volume to a normal level for easier listening.
2. To change or to vary the pitch, intensity, or tone; such as, a person's voice or a musical instrument: Jackie had to modulate her violin so the four strings had the correct pitches.

The TV announcer was modulating his voice in order to avoid speaking in a monotone or one unvaried pitch with little or no inflection or cadence.

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