1. To treat a disease with pharmaceutical drugs or prescriptions: Rebecca was so sick that her doctor had to medicate her so she could be healthy again.

Doctor Nelson wants to medicate James, her patient, with a different prescription because he apparently has developed a strange allergy to the other drug.

2. To include healing substances for treatment of an unhealthy condition: One of the shampoos that Erla has was medicated with a therapeutic chemical to prevent dandruff from developing on her head.
3. To chemically infuse a curative fluid with ingredients that improve one's bodily injuries: After falling on the ice and hurting herself badly, Lynn’s mother had to medicate her pains and bruises with a special ointment from the drug store.