1. To mark someone or something with a spot, a blotch, or a blemish: In order to avoid losing her clothing while she was in the hospital, Aurora maculated all of her clothing with a large 'X'.
2. To spot or to mark with changes in the color of skin that is neither raised nor depressed, or any anatomical structures having the form of a spot or stain: The disease caused the patient’s skin to maculate with dark brown spots in a distinctive pattern.