1. A round or spherical body: Mary's parents asked Susi if she would like to go out to the garden and play with her red and white globus before lunch.
2. In medicine, a lump or swelling: Suddenly Tom had the sensation of a globus, or lump in his throat, and couldn't speak to his mother.
3. In leprology, any of the brown bodies sometimes found in the granulomatous lesions of leprosy: A globus is considered to be a macrophage swelling contaning leprosy bacillis as seen in lepromatous leprosy.