The extremities are most often affected, but it can occur in the intestines and gallbladder, too. Internal gangrene may be a complication of strangulated hernia, appendicitis, cholecystitis, or thrombosis of the mesenteric arteries to the intestines.2. Etymology: gangrene comes from Greek ganggraina, denoting "an eating sore that ends in mortification" or "death" (of the flesh) and subsequently a rotting of the affected parts.
The causes or origins of gangrene
Gangrene is usually caused by obstruction of the blood supply to an organ or tissue, possibly resulting from inflammatory processes, injury, or degenerative changes; such as, arteriosclerosis.
Arteriosclerosis is a disease in which thickening, hardening, and the loss of elasticity of the arterial walls result in impaired blood circulation which develops with aging, and in hypertension, diabetes, hyperlipidemia, and other conditions.
It is commonly a sequela, or a secondary consequence or result, of boils, frostbite, crushing injuries, or diseases; such as, diabetes mellitus (severe, chronic form of diabetes) and Raynaud's disease (a circulatory disorder caused by insufficient blood supply to the hands and feet and resulting in cyanosis, numbness, pain, and, in extreme cases, gangrene).
The part of the body that dies from gangrene is known as a slough (for soft tissues) or a sequestrum (for bone). The dead matter must be removed before healing can take place.
The tissue simply dries up and shrivels.
The bacteria generate gas and pus. Gas gangrene is an acute, painful, dangerous condition.