Fibronectins are thought to function as adhesive ligandlike molecules that play a role in contact inhibition; also known as large external transformation sensitive protein (LETS), which is reduced after cells become transformed.2. Glycoproteins found on the surfaces of cells, particularly in fibrillar structures.
The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor viii. The forms present in plasma are called cold-insoluble globulins.