1. A system for determining the environmental influences on human health and disease which include scientific advances that may be used in the identification, quantification, and control of environmental impacts on human health.

Exposome represents everything a person is exposed to in the environment including stress, diet, lifestyle choices, recreational and medicinal drug use, and infections; and it changes throughout life as our bodies, diets, and lifestyles change.

2. The record of all exposures, both internal and external, that an individual receives over his or her lifetime, from conception onward.

These exposures range from chemicals in the environment to the body’s response to infection or psychological stress.

3. Everything that a person encounters in daily life; from diet and drug use to stress, and what risks these exposures pose to an individual's health, and to unravel the causes of disease.

As biomonitoring tools become wearable to monitor an individual's exposure to environmental pollutants, and when such devices can work in real time, people will have better control of their exposome existence.

In this way, the exposome could pave the way for the personalized medicine that the human genome has promised but which has not yet been achieved.

4. An approach using various genomic, proteomic (structure and analysis of proteins occurring in living organisms), and metabolomic (chemical reactions in living organisms to maintain life) methods to gather the information needed to characterize the exposome; for example, measuring gene expression, protein adducts, metals, and metabolites in human blood, and then using data analysis to sort out which ones are related to a disease.