1. In medicine, a reference to a condition caused by dystrophy: Dystrophication is the progressive change that may result from defective nutrition of a tissue or organ.

Dystrophication relates to or is caused by faulty nutrition.
2. In ecology, with reference to a lake or pond, having too low an accumulation of dissolved nutrients to support abundant plant life: Dystrophication is another description of a lake or pond that contains highly acid, brownish waters filled with undecayed plant materials, and eventually developing into a peat bog or marsh.

Dystrophication refers to a lake with high humus material, sparse bottom fauna, and low dissolved oxygen.