1. A lack of interest or ignoring someone or something or treating others as unimportant: David showed a blatant disregard for the traffic law when he exceeded the speed limit as he drove home from the party.

The terrorists have been behaving in total disregard for human life.

To pay no attention to, to take no notice of: Disregarding the cold weather, Joe and his family played outside all day.

Michael disregarded his mother's advice about getting ready as soon as possible and so he didn't get to school in time.