1. To remove poisonous substances or to transform them into something harmless: Jeff’s nose was bothering him so much because he couldn’t breath properly and so the doctor gave him some special nose drops in order to detoxicate the tissues which were posing his breathing problems.
2. To treat an alcoholic or drug addict by using a controlled withdrawal of the addictive substance: Greg, who drank too much wine and beer, was strongly encouraged by his friends to have himself detoxicated in a special hospital.