1. To throw something out of a window: Before toilets were invented and widely used, people in the past defenestrated their human wastes out on the streets in cities and were even defenestrating such excreta on people who were walking by the buildings below.
2. Etymology: The verb form was actually derived from the noun defenestration, and is composed of de-, "from, of" + fenestra "window". Fenestra is used in French fenêtre and in German Fenster.

Although the following image represents a noun, it also illustrates the meaning of this verb.

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1. A reference to something that is thrown out of a window: Tom recovered his defenestrated notebook that landed outside in the flowerbed when his brother had an angry fit.
2. In computer language, indicating the removal of a Windows's program from a computer: Sharon thanked her brother for the defenestrated Microsoft windows's program he took off the day before.