1. To restrict or to limit the ability to move or to relocate; to stay in a specific location: The doctors tried hard to confine the spread of the new virus in order to protect the large population.

The students were instructed to confine their written comments to just one page.

2. To keep or to cause a person to stay in something; such as, a bed or a wheelchair: After the accident, Morgan was confined to sitting in a wheelchair until his injured leg would get better.