calami-, calamit- +

1. Very miserable; involved in deep distress; oppressed with infelicity; wretched from misfortune.
2. Producing distress and misery; making wretched; applied to external circumstances; such as, a calamitous event.
3. Full of misery; distressful; wretched; applied to a situation or condition.
4. Causing great trouble, tragedy, or disaster.

In a manner that brings great distress or destruction.

Deep distress; wretchedness; misery; the quality of producing misery.

1. A disastrous event resulting in great loss and misfortune.
2. A great misfortune or disaster; such as, a flood or a serious injury.
3. A grievous affliction; adversity; misery: "We are just beginning to see the calamity of the war in Iraq.
4. An event that brings terrible loss, lasting distress, or severe affliction.
5. Dire distress resulting from loss or tragedy.

Dire financial or economic distress created by fiscal mismanagement.