You searched for: “most adverse
adverse (ad VURS, AD vurs") (adjective), more adverse, most adverse
1. Relating to someone or something that is opposed to or hostile toward another person or thing; unfavorable and negative: Adverse winds prevented the plane from arriving on time.

Adverse winds usually reduce the speed of sailing vessels.

When striving to achieve a worthy objective, everyone should not be discouraged by adverse criticism.

High interest rates are adverse to increasing the sales of houses.
2. Etymology: from Old French avers (Modern French adverse); from Latin adversus, "turned against"; therefore, "hostile"; past participle of advertere, from ad-, "to" + vertere, "to turn".

Conflicting with and contrary to one's interests; unfortunate.
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Word Entries at Get Words: “most adverse
Opposing and acting in a contrary way; conflicting and hostile to one's interests. (1)