1. A disgusting feeling about all of mankind; or a profound morbid distrust of human beings, individually and collectively: Being informed daily by the media and seeing and hearing about the never-ending disasters and wars around the world, a sense of misanthropy has developed in some people, causing them to stay home and not to go traveling to other places anymore.
2. A pessimistic distrust of people in general which is expressed in thoughts and behavior: After being extremely disappointed by his school friends, when he was young; and his girlfriend, when she stole his money and went away with another guy, Martin developed a misanthropy and decided he would live by himself and not get involved with any further relationships.