Hypertrophy and fibrosis of the skin and subcutaneous tissue, especially of the lower extremities and genitalia, due to long-standing obstructed lymphatic vessels, most commonly after years of infection by the filarial worms Wuchereria bancrofti or Brugia malayi.

Swelling of the scrotum resulting from chronic lymphatic obstruction.

elephantiasis is a chronic obstruction of the lymphatics with hypertrophy (swelling) of the skin and subcutaneous tissues (pachyderma); usually affecting dependent areas such as the upper or lower limbs, or external genitalia.